Bismuth ethanedithiol
WebAug 4, 2015 · Bismuth thiols (BTs) are antimicrobial agents with great potential to prevent and treat biofilms. The active ingredient in BTs is bismuth- a popular, over-the-counter, … WebMar 20, 2024 · Synergistic combination therapy is believed to be more effective in the treatment of infections related to biofilms. Hence, a niosomal drug formulation consisting of bismuth-ethanedithiol and tobramycin was developed and its antibacterial effect was tested through the inhibition of biofilm formation and reduction of N-acyl homoserine …
Bismuth ethanedithiol
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WebNov 12, 2012 · The contribution of bismuth ethanedithiol to the MICs was assessed by exposing the aforementioned bacterial strains to different concentrations of BiEDT-TOB and LipoBiEDT-TOB, with a starting con- WebMay 23, 2014 · The arsenal of conventional antipseudomonal antibiotic drugs include the extended-spectrum penicillins, cephalosporins, carbapenems, monobactams, polymyxins, fluoroquinolones, and aminoglycosides but their toxicity and/or increasing antibiotic resistance are of particular concern.
WebJun 1, 2024 · In addition, bismuth-ethanedithiol (BiEDT) inhibits the exopolysaccharide (EPS), Lipopolysaccharide (LPS) and alginate production by P. aeruginosa [9]. Due to the important role of quorum sensing in biofilm formation, researchers are looking for combination of drugs to inhibit this phenomenon in P. aeruginosa. WebConclusions: These data suggest that treatment of P. aeruginosa with tobramycin and bismuth, as measured by the changes in quorum sensing, virulence factors and biofilms, is most effective when delivered as a liposomal formulation at a lower concentration compared with the free formulation. Publication types Research Support, Non-U.S. Gov't
WebBismuth-dimercaprol, at a fraction of the minimal inhibitory concentration, reduced alginate expression by 67% in P. aeruginosa, whereas subinhibitory bismuth-ethanedithiol (BisEDT) reduced alginate by 92% in P. syringae.
WebDec 1, 2003 · Bismuth-thiols (BTs) are a new class of antibacterial agents, with antibiofilm activity against Gram-positive and -negative bacteria. 22 – 25 The thiol component functions as a lipophilic carrier that promotes bismuth uptake into bacteria, thus enhancing the effects of bismuth up to 1000-fold. 22 Once inside the cell, bismuth acts as a metabolic …
Web1,2-Ethanedithiol (EDT) is an organosulfur compound that is used as an organic building block in chemical synthesis. It is also used as a ligand for metal ions to prepare metal … how do bolts and nuts workWebJun 15, 2011 · Bismuth‐ethanedithiol incorporated in a liposome‐loaded tobramycin formulation modulates the alginate levels in mucoid Pseudomonas aeruginosa Misagh … how do bolts failWebThe effect of tobramycin incorporated with bismuth-ethanedithiol loaded on niosomes on the quorum sensing and biofilm formation of Pseudomonas aeruginosa. … how do bond funds make moneyWebEfficacy of liposomal bismuth-ethanedithiol-loaded tobramycin after intratracheal administration in rats with pulmonary Pseudomonas aeruginosa infection Abdel Omri 2013, Antimicrobial agents and chemotherapy how do bombs work in enlistedWebFeb 15, 2010 · These data suggest that treatment of P. aeruginosa with tobramycin and bismuth, as measured by the changes in quorum sensing, virulence factors and … how do bond auctions workWebBismuth-ethanedithiol inhibited 10 methicillin-resistant Staphylococcus epidermidis strains at 0.9 to 1.8, Staphylococcus aureus ATCC 25923 at 2.4, and S. epidermidis ATCC 12228 at 0.1 mMBi31. how do bombs affect the environmentWebAug 26, 2010 · Bismuth-Ethanedithiol: A Potential Drug to Treat Biofilm Infections of Medical Devices Produced by Staphylococcus Epidermidis … how much is dark worth