Cisplatin apoptosis induction
WebSep 5, 2011 · The major signaling cascade that bridges cisplatin-induced DNA lesions to apoptosis involves the sequential activation of the ataxia telangiectasia mutated (ATM)- and RAD3-related protein (ATR,... WebWe have treated four prostate tumor cell lines, DU-145, PC-3, LNCaP and 22RV1 with various concentrations of cisplatin in order to check for influence on viability and for …
Cisplatin apoptosis induction
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WebAt the end of the execution phase, the apoptotic signal must come back to the nucleus to produce internucleosomal DNA degradation. Therefore, the induction of apoptosis from … WebAdditionally, to determine the effects of the combination of TAS and cisplatin on the apoptosis of NSCLC cells, flow cytometry was used to detect the apoptosis rate in A549 cells treated with cisplatin alone or combination therapy. ... Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA …
WebCisplatin helps in the treatment of various types of cancers in the body like such as ovarian, lung, head and neck, testicular and bladder. 5 Cisplatin is efficient in use against various types of cancers such as germ cell tumors, sarcomas, carcinomas as well as lymphomas. WebAug 13, 2024 · Whereas hederagenin per se failed to cause any apoptosis, the combination of hederagenin and cisplatin significantly enhanced apoptotic cell death as compared …
WebJun 13, 2014 · In ovarian cancer cells that have developed acquired cisplatin resistance, both ERK activation and autophagy induction are increased. Importantly, knockdown of ERK or inhibition of autophagy promotes cisplatin-induced apoptosis in … WebJan 16, 2024 · One of the most common treatments for this type of cancer is chemotherapy by cisplatin, which induces apoptosis in cancer cells. Apoptosis is a type of …
WebApr 2, 2024 · In our results, the group with cisplatin delivery-based electrospray (CDES) at 6 kV had an apoptosis of cancer cells approximately two times more than the group treated with cisplatin alone.
WebAt a cisplatin concentration of 20 microM, 22RV1 and DU-145 cells showed approximately 22% and 18% and PC-3 and LNCaP cells showed approximately 4 and 10% dead cells, respectively. When checking for apoptosis induction, the differences among the cell lines became even more evident. high performance struts and shocksWebCisplatin is the most important and efficacious chemotherapeutic agent for the treatment of advanced gastric cancer. Cisplatin forms inter- and intrastrand crosslinked DNA adducts … high performance subaru engineshigh performance sunglassesWebApr 28, 2011 · Furthermore, in agreement with a previous report, the apoptosis induced by cisplatin is dependent on the cell cycle. Indeed, cell death by apoptosis is significantly inhibited in nonproliferating cells (Fig. 5; ... Retinoid-related molecules require caspase 9 for the effective release of Smac and the rapid induction of apoptosis, ... high performance street carsWebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … high performance suv 2011WebAug 30, 2024 · Cisplatin-induced apoptosis and necroptosis were also effectively suppressed by melatonin in mouse renal tubular epithelial (TCMK-1) cells. These results reveal a novel mechanism underlying the therapeutic effect of the hormone against cisplatin-induced AKI. ... resulting in induction of cytochrome c release into cytosol and … high performance subaru partsWebWe have shown previously that β-elemene increases cisplatin cytotoxicity and enhances cisplatin sensitivity via blocking cell cycle progression at G2/M phase in resistant ovarian tumor cells. In the current study, we asked whether β-elemene-augmented cisplatin activity in ovarian carcinoma cells is mediated through the induction of apoptosis. high performance supplements for men over 55