Phospho-p53 ser15
WebThe NeuroMab™ anti-Phospho-p53 (Ser15) antibody (Rodent Specific) recognizes endogenous levels of p53 protein only when phosphorylated at Ser15. Expression Host … WebThere are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization. p53 has been characterized to play a role in …
Phospho-p53 ser15
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WebPhosphorylated by NUAK1 at Ser-15 and Ser-392; was initially thought to be mediated by STK11/LKB1 but it was later shown that it is indirect and that STK11/LKB1-dependent phosphorylation is probably mediated by downstream NUAK1. It is unclear whether AMP directly mediates phosphorylation at Ser-15. WebApr 15, 2013 · However, AMPK also induces phosphorylation of p53 at Ser15, which stabilizes the protein and leads to mitochondrial accumulation of p53. At the mitochondrial surface, phospho-p53 adjoins and rearranges the Bak–Bcl-x L complex (Fig. S3N), resulting in conformational activation of Bak and apoptotic sensitization. This mechanism may act …
WebThe -p53 (Ser15) Assay is a sandwich immunoassay Phospho (Figure 1). MSD provides a plate that has been pre-coated with capture antibody for phospho-p53. WebActivation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis . DNA damage induces phosphorylation of p53 at Ser15 and Ser20 and leads to a reduced …
WebPhospho-p53 (Ser15) Antibody (MA5-15229) in ICC/IF. Immunofluorescence analysis of Phospho-p53 (Ser15) was performed using 70% confluent log phase HCT116 cells … WebThe intense phosphorylation of p53-Ser15, combined with activation of ATM and Chk2 (involving centrioles) as well as phosphorylation of H2AX seen in the untreated mitotic …
WebThe phospho-p53 (Ser15) antibody detects ~53 kDa phosphorylated p53 at Ser15. It does not react with non-phosphorylated p53 or p53 phosphorylated at other sites.
Web80195-1-RR targets Phospho-P53 (Ser15) in WB, FC, ELISA applications and shows reactivity with Human samples. Background Information P53 is a 53 kDa protein that is activated in response to alteration of normal cell homeostasis, including DNA damage, nutrient starvation, heat shock, virus infection, pH change, hypoxia, and oncogene … eastchester summer concertsWebPhospho-p53 (Ser15) (16G8) Mouse mAb detects endogenous levels of p53 only when phosphorylated at serine 15. The antibody does not cross-react with p53 phosphorylated … cubed ham ideasWebPhospho-p53 (Ser15) Translocation Assay Kit (Cell-Based) (ab284565) (K966) provides a simple and complete assay in a ready to use format to visualize the nuclear translocation of activated p53 in mammalian cells. … cubed ham nutritionWebB, The relative protein intensities of p53, phospho-p53 (Ser15), phospho-p53 (Thr55), p21, and survivin as compared with the intensity of α-tubulin. The intensity of each band was quantified using Quantity One software. Data are means ± SD, n = 3. The experiments were conducted in triplicate. eastchester tanningWeb67826-1-Ig targets Phospho-P53 (Ser15) in WB, FC, ELISA applications and shows reactivity with Human samples. Background Information TP53, also known as P53 and NY-CO-13, belongs to the p53 family and has 9 isoforms. In SDS-Page, the observed molecular weight is about 53 kDa. cubed ice vs crushed iceWebOct 16, 2024 · Upon genotoxic stress, ATM can directly phosphorylate p53 at Ser15 52 - 54 and, in addition, mediates p53 Ser20 phosphorylation via activation of its direct substrate CHK2, which functions as a p53 Ser20 kinase. 55 Additionally, ATM was also reported as a p53 Ser46 kinase 50 (Figure 4 b). eastchester tapas cuccinaWebJun 7, 2014 · Serine 15 is the primary target of the DNA damage response on the p53 protein and is phosphorylated by both the ATM and ATR protein kinases (discussed in … cubed ham salad recipe for sandwiches