WebApr 28, 2014 · In vitro co-immunoprecipitation studies in prostate cancer cell extracts demonstrated that these compounds disrupted the HIF-1α/p300 complex. The downstream effects of inhibiting the HIF-1α/p300 interaction were evaluated by determining HIF-1α target gene expression at the mRNA and protein levels. Webphosphopyruvate hydratase complex Complete GO annotation on QuickGO Phenotypes & Variants Variants Structure 3D structure databases AlphaFoldDB B5VSR2 SMR B5VSR2 …
GCA_000702925_01970 protein (Methylomonas sp. LW13)
WebAbstract. Inactivation of the von Hippel–Lindau tumor-suppressor protein (pVHL) is the signature “truncal” event in clear cell renal cell carcinoma, which is the most common … Phosphopyruvate hydratase, usually known as enolase, is a metalloenzyme (EC 4.2.1.11) that catalyses the conversion of 2-phosphoglycerate (2-PG) to phosphoenolpyruvate (PEP), the ninth and penultimate step of glycolysis. The chemical reaction is: 2-phospho-D-glycerate See more In humans there are three subunits of enolase, α, β, and γ, each encoded by a separate gene that can combine to form five different isoenzymes: αα, αβ, αγ, ββ, and γγ. Three of these isoenzymes (all homodimers) are … See more Using isotopic probes, the overall mechanism for converting 2-PG to PEP is proposed to be an E1cB elimination reaction involving a carbanion intermediate. The following detailed mechanism is based on studies of crystal structure and See more Small-molecule inhibitors of enolase have been synthesized as chemical probes (substrate-analogues) of the catalytic mechanism of the enzyme and more recently, have been investigated as potential treatments for cancer and infectious diseases. … See more Enolase is a member of the large enolase superfamily. It has a molecular weight of 82,000-100,000 Daltons depending on the isoform. In human alpha enolase, the two subunits are See more In recent medical experiments, enolase concentrations have been sampled in an attempt to diagnose certain conditions and their severity. For example, higher concentrations of … See more • Holt A, Wold F (December 1961). "The isolation and characterization of rabbit muscle enolase". The Journal of Biological Chemistry. 236 (12): … See more • Enolase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more cyst bleeding into itself
Targeting HIF2 in Clear Cell Renal Cell Carcinoma
WebFeb 1, 2011 · Phosphopyruvate hydratase activity Specific Function Appears to have a function in striated muscle development and regeneration. Pfam Domain Function Enolase_C ( PF00113) Enolase_N ( PF03952) Transmembrane Regions Not Available Cellular Location Cytoplasm Gene sequence WebStructure. ENO3 is one of three enolase isoforms, the other two being ENO1 (ENO-α) and ENO2 (ENO-γ). Each isoform is a protein subunit that can form hetero-or homodimers of the following combinations: αα, αβ, αγ, ββ, and γγ.. Gene. The ENO3 gene spans 6 kb and contains 12 exons, though the first exon is an untranslated region and, thus, non-coding. . … Webホスホピルビン酸ヒドラターゼ（Phosphopyruvate hydratase）またはエノラーゼ（Enolase）は、解糖系に関わる酵素である。. この酵素は、グルコースからピルビン酸に至るまでの最後から2番目のステップである、2-ホスホグリセリン酸がホスホエノールピルビン酸に変換される反応を触媒する。 cyst blood